Genomics

What is genomics?

De novo sequencing based genomics - relative strengths of PacBio, BioNano and Dovetail. Value of other long read approaches - structural variation and the broadest view of the genome.

Genome resequencing - variant discovery and the finest differences - Illumina platforms, Ion Torrent

Genetic variant analysis through high density DNA microarrays.

Genome study design

Clinical, agricultural and biotechnological thoughts.

Relative importance of number of individuals studied (crop breeding programme or GWAS study) vs the need for whole chromosome arm information and integration of genomic data with physical and genetic maps.

Importance of strategy

Need for reproducible research Perfect genomes and cumulative information - scaffolds and contigs Balance between cost effectiveness and data utility